Onset and Recurrence Characteristics of Chinese Patients with Noncardiogenic Ischemic Stroke in Chinese Medicine Hospitals
Release time: Sept 29,2022
Reading volume: 561
Abstract：
Objective:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in China.Methods:A prospective,multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3,2016 to February 17,2019.A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk factors.Additionally,stroke recurrence was defined as a primary outcome indicator.Results:A total of 327（12.78 %） patients endured recurrence events,1,681（65.72%） patients were men,and the average age was 63.33±9.45 years.Totally 1,741（68.06%） patients suffered first-ever ischemic stroke,1,772（69.27%） patients reported to have hypertension,and1,640（64.11%） of them reported dyslipidemia,1,595（62.35%） patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment（TOAST） classification.Specifically,1,271（49.69%） patients were considered as qi-deficient constitution,and 1,227（47.97%） patients were determined as stagnant blood constitution.There were 1,303（50.94%） patients diagnosed as blood stasis syndrome,1,280（50.04%） patients exhibited phlegm and dampness syndrome and 1,012（39.56%） patients demonstrated qi deficiency syndrome.And 1,033（40.38%）patients declared intracranial artery stenosis,and 478（18.69%） patients reported carotid artery stenosis.The plaque in 1,508（41.36%） patients were of mixed.Particularly,41.09% of them demonstrated abnormal levels of glycated hemoglobin（HbA1 c） levels.Conclusions:Recurrence in minor and small-artery stroke cannot be ignored.Hypertension,dyslipidemia,abnormal HbA1 c,intracranial artery stenosis and carotid plaque were more common in stroke patients.Particularly,phlegm-dampness and blood stasis syndromes,as well as qi deficiency and blood stasis constitutions,were still the main manifestations of stroke.（Trial registration at ClinicalTrials.gov,No.NCT03174535）
Keywords：
noncardiogenic ischemic stroke;Chinese medicine hospital;onset characteristics;recurrence
Objective:To delineate the onset and recurrence characteristics of noncardiogenic ischemic stroke patients in China.Methods:A prospective,multicenter and registry study was carried out in 2,558 patients at 7 representative clinical sub-centers during November 3,2016 to February 17,2019.A questionnaire was used to collect information of patients regarding CM syndromes and constitutions and associated risk factors.Additionally,stroke recurrence was defined as a primary outcome indicator.Results:A total of 327（12.78 %） patients endured recurrence events,1,681（65.72%） patients were men,and the average age was 63.33±9.45 years.Totally 1,741（68.06%） patients suffered first-ever ischemic stroke,1,772（69.27%） patients reported to have hypertension,and1,640（64.11%） of them reported dyslipidemia,1,595（62.35%） patients exhibited small-artery occlusion by The Trial of Org 10172 in Acute Stroke Treatment（TOAST） classification.Specifically,1,271（49.69%） patients were considered as qi-deficient constitution,and 1,227（47.97%） patients were determined as stagnant blood constitution.There were 1,303（50.94%） patients diagnosed as blood stasis syndrome,1,280（50.04%） patients exhibited phlegm and dampness syndrome and 1,012（39.56%） patients demonstrated qi deficiency syndrome.And 1,033（40.38%）patients declared intracranial artery stenosis,and 478（18.69%） patients reported carotid artery stenosis.The plaque in 1,508（41.36%） patients were of mixed.Particularly,41.09% of them demonstrated abnormal levels of glycated hemoglobin（HbA1 c） levels.Conclusions:Recurrence in minor and small-artery stroke cannot be ignored.Hypertension,dyslipidemia,abnormal HbA1 c,intracranial artery stenosis and carotid plaque were more common in stroke patients.Particularly,phlegm-dampness and blood stasis syndromes,as well as qi deficiency and blood stasis constitutions,were still the main manifestations of stroke.（Trial registration at ClinicalTrials.gov,No.NCT03174535）
Keywords：
noncardiogenic ischemic stroke;Chinese medicine hospital;onset characteristics;recurrence
